Mullan’s Alzheimer Research Has Helped Develop Treatment For The Disease

FOR IMMEDIATE RELEASE
Sarasota, Florida, United States of America (Free-Press-Release.com) January 3, 2012 --

Alzheimer’s disease is considered to be the most common kind of dementia in elderly people. It is characterized by the accumulation of a molecule known as amyloid beta in brain. Dr. Mullan’s Alzheimer research has revealed that a molecule CD40L is elevated in the persons suffering from the disease. The studies have shown that the stimulation of this molecule induces increase in amyloid beta levels in the cellular models of disease. Furthermore, the CD40L simulation of cells which are extremely important for defense of nervous system increases pro-inflammatory molecules called Cytokines. One of the cytokines is GM-CSF (granulocyte macrophage colony stimulating factor) that is involved in the inflammation responses in brain.

Dr. Michael Mullan’s Alzheimer research demonstrates that there is a correlation between Alzheimer’s disease and increases in the pro-inflammatory cytokines. The stimulation of CD40L causes an increase in the levels of both amyloid beta and GM-CSF in the AD cell models. The studies show that when these cells are treated with GM-CSF, a time-dependent significant increase in amyloid beta levels occurs. Blocking the GM-CSF reduces the production of CD40L induced amyloid in dose dependent manner. The Roskamp Institute, headed by Dr. Mullan is one of many sites that have been selected to carry out clinical trial on Alzheimer’s disease using vaccine approach. The institute is committed to conducting scientific research to find out safe and effective drug therapies to treat various mental disorders, thus promoting healthy aging.

About Dr Michael Mullan
Dr Michael Mullan has been working in the biomedical field for many years. He is a leading researcher with special expertise in assessment of the earliest cognitive symptoms and stages of Alzheimer’s disease. Mullan’s Alzheimer research works are also published in various articles which help students and researchers for making new discoveries. Find out more about his Alzheimer research works, by browsing through www.rfdn.org or www.mullanalzheimer.com or www.mullanalzheimer.info.

MULLAN ALZHEIMER