New Evidence of Glucosamine HCl Anti-Cancer Properties

FOR IMMEDIATE RELEASE
Punta Gorda, Florida, United States of America (Free-Press-Release.com) February 23, 2012 -- Toxicology in Vitro, the Official Journal of the European Society of Toxicology in Vitro, published a study in their February 2012 issue that presents evidence of anti-cancer properties of glucosamine hydrochloride (glucosamine-HCl) in human oral cancer cells.

Studies have provided evidence of the cancer-fighting properties of glucosamine in cancers such as prostate, breast, lung and leukemia. No studies to date have shown the effects in human oral cancer cells.

The study examined anti-proliferative, growth suppressive and pro-apoptotic effects of glucosamine-HCl on YD-8 human oral squamous cell carcinoma (OSCC) cells. The YD-8 cells were grown in a humidified condition at a constant temperature in a laboratory. Some of the cells were treated with Glucosamine-HCl while others were not.

The results show that glucosamine-HCl has strong anti-proliferative, anti-survival, and pro-apoptotic effects on the cancerous human oral cells. The data also shows the ability of glucosamine-HCl to additionally repress expression of HIF-1⍺, a transcription factor that induces the formation of new blood vessels, especially those that supply oxygen and nutrients to cancerous tissues.

The study claims that its findings suggest that glucosamine-HCl may be eventually used as an anti-cancer agent against human OSCC cells. More studies need to be conducted, including studies with actual human subjects.

“Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-depended aptosis and down-regulation of HIF-1⍺” Chang-Wook Jung, Jeong-Rang Jo, Sang-Han Lee, Yu-Kyoung Park, Nak-Kyun Jung, Dae-Kyu Song, Jaehoon Bae, Ki-Young Nam, Jung-Sook Ha, In-Sook Park, Gy-Young Park, Byeong-Churl Jang, Jong-Wook Park, Toxicology in Vitro, online February 18, 2012: http://www.journals.elsevier.com/toxicology-in-vitro.

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