DNA damage caused by oxidative radicals is associated with aging, inflammation, carcinogenesis, Parkinson’s & Alzheimer’s. When exposed to oxidative radicals, 8-hydroxy-2’-deoxyguanosine is formed.
United States of America (Press Release) March 3, 2008 --
DNA damage caused by oxidative radicals is associated with aging, inflammation, carcinogenesis, Parkinson’s and Alzheimer’s diseases. When exposed to oxidative radicals, 8-hydroxy-2’-deoxyguanosine (8-oxo-dG) is formed and can serve as a sensitive indicator of physiological and environmental damage to DNA. This mouse monoclonal antibody specifically binds to 8-hydroxy-2’-deoxyguanosine within DNA in H2O2-treated cells.
It can be used to detect oxidative damage by ELISA and immunocytochemistry. For optimal outcomes, cells should be grown on a surface that allows for fixation and direct labeling such as sterile chamber slides and coverslips. This antibody is provided as purified immunoglobulin from mouse ascites in 1X PBS containing 0.01% sodium azide.
Sufficient antibody is provided for approximately 50 slides, when a 1:250 dilution is used (Cat# 4354-MC-050). For details, contact Trevigen by phone at 800-873-8443, by email info@trevigen.com or visit the website www.trevigen.com.
About Trevigen:
Trevigen is a long standing provider of quality kits and reagents for researchers investigating programmed cell death, DNA damage and repair, cell differentiation and angiogenesis. Trevigen recently launched Anti-8-oxo-dG Monoclonal Antibody (Clone 2E2) as part of it DNA Damage product line.
It can be used to detect oxidative damage by ELISA and immunocytochemistry. For optimal outcomes, cells should be grown on a surface that allows for fixation and direct labeling such as sterile chamber slides and coverslips. This antibody is provided as purified immunoglobulin from mouse ascites in 1X PBS containing 0.01% sodium azide.
Sufficient antibody is provided for approximately 50 slides, when a 1:250 dilution is used (Cat# 4354-MC-050). For details, contact Trevigen by phone at 800-873-8443, by email info@trevigen.com or visit the website www.trevigen.com.
About Trevigen:
Trevigen is a long standing provider of quality kits and reagents for researchers investigating programmed cell death, DNA damage and repair, cell differentiation and angiogenesis. Trevigen recently launched Anti-8-oxo-dG Monoclonal Antibody (Clone 2E2) as part of it DNA Damage product line.
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