DENOVA ROYAL COSMETIC NEUTRADERM MEGALOPOLIS Eye Mega Cream is an active cosmetic that inhibits the matrix metalloproteinase (MMP) enzymes that degrade and destroy the skin’s collagen network. 
United Kingdom of Great Britain & N. Ireland (Press Release) May 4, 2008 --
WHY NEUTRADERM?
NEU – Neurocosmetic,
NEUTRA – for Neutralizes Neurogenic inflammation,
NEUTRADERM – for Skin equilibrium.
The field of neurocosmetics has recently emerged as a promising new way to address cosmetic problems through an action on the cutaneous nervous system. The skin is richly innervated and contacts have been described between nerve fibers, keratinocytes and melanocytes. Neuropeptides produced in paracrine and autocrine manners by nerve cells as well as skin cells and immune cells serve as preferential messengers to maintain cutaneous homeostasis.
Rupture of this equilibrium by external or internal aggressions leads to
cosmetological disorders.
Our newest Line is NEUTRADERM MEGALOPOLIS, a true Neurocosmetic specifically designed to prevent and reverse signs of Neurogenic inflammation.
DENOVA ROYAL COSMETIC NEUTRADERM MEGALOPOLIS is an innovative tri-peptide linked to a lipid for optimal penetration and efficacy.
It calms and soothes irritated skin and helps to maintain and restore a normal skin sensitivity threshold.
DENOVA ROYAL COSMETIC PROJECTS has launched a non invasive cosmetic solution that mimics injection. This active is a cosmetic alternative to plastic surgery.
It resculpts the face from within thanks to a volumizing effect. Mega Cream optimized blend of Hyaluronic acid and Commiphora mukul extract, has a volumizing effect on the dermis and the hypodermis.
DENOVA ROYAL COSMETIC NEUTRADERM MEGALOPOLIS Eye Mega Cream fills up wrinkles from within by mechanical and physiological effects.
It limits subcutaneous volume loss. This active is vectorized toward specific facial areas thanks to a unique patented technology.
Young face tends to be convex, with nice curves: fleshy and smooth lips, full cheeks.
Every one with age, these lines are altered and become concave: hollowed cheeks, prominent chin… Replumping the skin from within offers new perspectives to fight against aging signs.
Nowadays, this mechanism is becoming a major stake for the cosmetic industry.
DENOVA ROYAL COSMETIC PROJECTS takes part of this trend by developing NEUTRADERM Megalopolis Eye Mega Cream, a cosmetic alternative to aesthetic surgery.
DENOVA ROYAL COSMETIC NEUTRADERM MEGALOPOLIS Eye Mega Cream is an active cosmetic that inhibits the matrix metalloproteinase (MMP) enzymes that degrade and destroy the skin’s collagen network.
With aging and often-stressful lifestyles or exposure to harmful environmental irritants, the activity of these enzymes increases, affecting the health of our extracellular matrix. It is very important to preserve this matrix while maintaining an enzymatic equilibrium.
Neuropeptides constitute a subclass of neuromediators. They consist in tiny strings of amino acids occurring naturally in our bodies where they exert their effects by interacting with specific receptors embedded in the surface of cells. In the skin, they are produced and released by nerve cells but also by cutaneous and immune cells, under physiological circumstances. They play important roles in inflammation and immunomodulation.
For instance: calcitonin gene-related peptide (CGRP), adrenomedullin (AM), bradykinin (BK), substance P (SP), neuropeptide Y (NY), vasoactive intestinal polypeptide (VIP), as well as proopiomelanocortins (POMC)
derivatives are neuropeptides considered as key players in neurogenic inflammation of the skin 10.
Keratinocytes and fibroblasts are major targets of these neuropeptides.
While traditionally the sources of cosmetic actives used to be limited to plant extracts, essential oils, and vitamins, nowadays synthetic molecules can be engineered for this purpose. The beauty of the process is that highly specific ingredients, that mimic natural sources, can be designed with increased efficacy at lower dosage. Based on our developing knowledge of the complex physiology of skin, biomimetic peptides are created and shaped in such a way that they can substitute for natural skin neuropeptides to address various cosmetic needs. Biomimetic peptides are the next generation of DENOVA ROYAL COSMETIC PROJECTS skin care products.
To use: Morning and evening, after removing make-up, lightly dab around eyes, starting from outside and moving inwards.
NET WT. 15 mle/0.5 OZ.
Recommended price: 98 Euro.
Developed in Scotland (UK) by BEAURA Royal Cosmetic Projects.
WHY NEUTRADERM?
NEU – Neurocosmetic,
NEUTRA – for Neutralizes Neurogenic inflammation,
NEUTRADERM – for Skin equilibrium.
The field of neurocosmetics has recently emerged as a promising new way to address cosmetic problems through an action on the cutaneous nervous system. The skin is richly innervated and contacts have been described between nerve fibers, keratinocytes and melanocytes. Neuropeptides produced in paracrine and autocrine manners by nerve cells as well as skin cells and immune cells serve as preferential messengers to maintain cutaneous homeostasis.
Rupture of this equilibrium by external or internal aggressions leads to
cosmetological disorders.
Our newest Line is NEUTRADERM MEGALOPOLIS, a true Neurocosmetic specifically designed to prevent and reverse signs of Neurogenic inflammation.
DENOVA ROYAL COSMETIC NEUTRADERM MEGALOPOLIS is an innovative tri-peptide linked to a lipid for optimal penetration and efficacy.
It calms and soothes irritated skin and helps to maintain and restore a normal skin sensitivity threshold.
DENOVA ROYAL COSMETIC PROJECTS has launched a non invasive cosmetic solution that mimics injection. This active is a cosmetic alternative to plastic surgery.
It resculpts the face from within thanks to a volumizing effect. Mega Cream optimized blend of Hyaluronic acid and Commiphora mukul extract, has a volumizing effect on the dermis and the hypodermis.
DENOVA ROYAL COSMETIC NEUTRADERM MEGALOPOLIS Eye Mega Cream fills up wrinkles from within by mechanical and physiological effects.
It limits subcutaneous volume loss. This active is vectorized toward specific facial areas thanks to a unique patented technology.
Young face tends to be convex, with nice curves: fleshy and smooth lips, full cheeks.
Every one with age, these lines are altered and become concave: hollowed cheeks, prominent chin… Replumping the skin from within offers new perspectives to fight against aging signs.
Nowadays, this mechanism is becoming a major stake for the cosmetic industry.
DENOVA ROYAL COSMETIC PROJECTS takes part of this trend by developing NEUTRADERM Megalopolis Eye Mega Cream, a cosmetic alternative to aesthetic surgery.
DENOVA ROYAL COSMETIC NEUTRADERM MEGALOPOLIS Eye Mega Cream is an active cosmetic that inhibits the matrix metalloproteinase (MMP) enzymes that degrade and destroy the skin’s collagen network.
With aging and often-stressful lifestyles or exposure to harmful environmental irritants, the activity of these enzymes increases, affecting the health of our extracellular matrix. It is very important to preserve this matrix while maintaining an enzymatic equilibrium.
Neuropeptides constitute a subclass of neuromediators. They consist in tiny strings of amino acids occurring naturally in our bodies where they exert their effects by interacting with specific receptors embedded in the surface of cells. In the skin, they are produced and released by nerve cells but also by cutaneous and immune cells, under physiological circumstances. They play important roles in inflammation and immunomodulation.
For instance: calcitonin gene-related peptide (CGRP), adrenomedullin (AM), bradykinin (BK), substance P (SP), neuropeptide Y (NY), vasoactive intestinal polypeptide (VIP), as well as proopiomelanocortins (POMC)
derivatives are neuropeptides considered as key players in neurogenic inflammation of the skin 10.
Keratinocytes and fibroblasts are major targets of these neuropeptides.
While traditionally the sources of cosmetic actives used to be limited to plant extracts, essential oils, and vitamins, nowadays synthetic molecules can be engineered for this purpose. The beauty of the process is that highly specific ingredients, that mimic natural sources, can be designed with increased efficacy at lower dosage. Based on our developing knowledge of the complex physiology of skin, biomimetic peptides are created and shaped in such a way that they can substitute for natural skin neuropeptides to address various cosmetic needs. Biomimetic peptides are the next generation of DENOVA ROYAL COSMETIC PROJECTS skin care products.
To use: Morning and evening, after removing make-up, lightly dab around eyes, starting from outside and moving inwards.
NET WT. 15 mle/0.5 OZ.
Recommended price: 98 Euro.
Developed in Scotland (UK) by BEAURA Royal Cosmetic Projects.
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