Doxycycline should be taken with a full glass of water or other liquid to avoid irritating your throat or stomach. Doxycycline can be taken with or without food. Doxycycline tablets should be swallowed whole rather than being chewed.

More common side effects of doxycycline may include: Angioedema (chest pain; swelling of face, around lips, tongue and throat, arms and legs; difficulty swallowing), bulging foreheads in infants, diarrhea, difficulty swallowing, discolored teeth in infants and children (more common during long-term use of tetracycline), inflammation of the tongue, loss of appetite, nausea, rash, rectal or genital itching, severe allergic reaction (hives, itching, and swelling), skin sensitivity to light, vomiting.

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